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KMID : 0043319950180050356
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Archives of Pharmacal Research
1995 Volume.18 No. 5 p.356 ~ p.360
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Synthesis of 1-Aryl-2-mercapto-4-aryl-1,6-dihydro-1,3,5-triaszine-6-thione and their Latentiation Products as Antithyroidal Agent
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Methrotra S.
Roychowdhury P.K.
Pandey K.K.
Srivastava P.K.
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Abstract
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Two new 1-aryl-2-benzylmercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thiones hvae been synthesized by known methods (Coerdeler et al., 1967). These triazines on treatment with thiourea as dealkylating agent, in acidic medium afforded the corresponding 1-ary-2-mercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thione which on further reaction with different carbonyl compounds and aryl-cyanamide ydrochloride affordered the related adducts. Some of these compounds show appreciable antithyroidal activity.
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KEYWORD
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Triazing thione, Mercaptotriazine, Aryl-cyanamide hydrochloride, carbonyl compounds, Antithyroida, activity
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